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50 l phosphate-buffered saline was used as negative and 0.01 U bovine GPX (Sigma Aldrich) as positive control, respectively

The hydroxy-proline (OH-Pro) content was determined according to 12 on the delipidated and dry residue obtained after the total lipids extraction

Gubert C, Stertz L, Pfaffenseller B et al (2013) Mitochondrial activity and oxidative stress markers in peripheral blood mononuclear cells of patients with bipolar disorder, schizophrenia, and healthy subjects

Although efficient, these approaches provide limited local delivery and substantial systemic exposure, restricting their clinical applicability