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Research published in 2023 demonstrated that GHK-Cu significantly upregulates genes associated with collagen I and III synthesis while simultaneously modulating matrix metalloproteinase (MMP) activity [1]

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In a related analysis, GHK was noted for its ability to reverse, in vitro, an aggressive gene-expression signature associated with metastatic behavior in certain tumor-cell datasets a striking observation that is nonetheless purely computational/in-vitro and not a therapeutic claim, and one that should be read alongside the founding finding that the same peptide can stimulate growth in neoplastic cells

Nuclear targets Nanocomposites that are developed for the purpose of nuclear-targeted therapies are mostly used to control gene expression, activate cell death, or stop cell division