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Neurometabolite levels in the brains of patients with autism spectrum disorders: A meta-analysis of proton magnetic resonance spectroscopy studies (N = 1501)

When possible, GSTF sequences were corrected on the basis of available ESTs

Intervention strategies fall into three categories: upstream inhibition of glycolytic enzymes (e.g., LDHA inhibitors) and lactate transporters (MCT1/4 inhibitors), direct targeting of the lactylation machinery (e.g., p300/CBP inhibitors), and combination therapies that integrate these metabolic approaches with conventional treatments ( Figure 2A )