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173 mTOR as an energy sensor The mTORC1 pathway detects and regulates cellular growth and survival in response to environmental, extracellular, and intracellular stresses, such as hypoxia, reduced ATP levels, and DNA damage

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Arterioscler Thromb Vasc Biol 2000

ACTIVATION PRESERVES GUT BARRIER INTEGRITY BY SUPPRESSING INTESTINAL EPITHELIAL CELL NECROPTOSIS: PROTECTIVE ROLE IN METABOLIC DYSFUNCTION-ASSOCIATED STEATOHEPATITIS Akiko Sugiyama 1 Susan Hagen 2 David Cohen 1 , 1 Brigham and Women's Hospital, Harvard Medical School, 2 Beth Israel Deaconess Medical Center, Harvard Medical School Background: Acyl-CoA thioesterase 12 (Acot12), a cytosolic enzyme that hydrolyzes acetyl-CoA into acetate, is expressed in small intestinal epithelial cells (IEC) and is markedly induced by high fat diet (HFD) feeding