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Consistent with this observation, PERMANOVA analysis demonstrated no statistically significant difference between pre- and post-intervention metabolomes (F = 0.2135, R = 0.0117, p = 0.857), suggesting that the GF-MKD did not induce large-scale global metabolic remodeling

demonstrated that elevated salivary cf-mtDNA levels serve as an independent predictor of poor prognosis in head and neck squamous cell carcinoma [107]