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By defining global and gene-specific DNA 5hmC modifications, we demonstrated that DMF induces 5hmC modifications to influence loci-specific chromatin structure through L2HGDH to reduce the levels of L2HG

For IE mRNAs, a viral transactivator called VP16 plays an important role in promoting their transcription by binding to cellular factors namely the octamer-binding protein 1 (Oct1) in epithelial cells and the host cell factor-1 (HCF-1), both in epithelial and neuron cells (Herrera and Triezenberg, 2015)

These signaling networks orchestrate cytokine release, leukocyte recruitment, endothelial activation, apoptosis, and fibrotic remodeling, ultimately contributing to sustained renal damage and impaired recovery (Wang et al