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Bruscia, E.M

The genomic features overlapping with the features were identified using the DMAP inbuilt Geneloc function and then with GenomicRanges with promoter overlaps (sourced from TxDb hg19 genomic data)

A key contributing factor to liver fibrosis is chronic inflammation, which drives hepatic stellate cell (HSC) activation through the recruitment of inflammatory cells, such as monocytes and macrophages

The proposed condensation domain C* (CesA_C2) 8 transfers the hydroxy group of D- O -Leu-D-Ala- S -PCP to the thioester carbon of L- O -Val-L-Val- S -PCP to form an ester bond resulting in the PCP-bound tetradepsipeptide L- O -Val-L-Val-D- O -Leu-D-Ala- S -PCP ( DP4 ) 24 , which is subsequently transferred to the serine hydroxy group of the CesB C-terminal TE domain (Fig