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10.1016/j.ebiom.2019.04.018 EBioMedicine

Mutations in SOD1 increase protein misfolding and lead to the production of insoluble SOD1 aggregates in cytoplasm

Nature 435 , 824827 (2005)

When initiated, SOD catalyzes the dismutation of the superoxide anion into H 2 O 2 and oxygen (O 2 ), reducing the risk of oxidative damage from superoxide, a highly reactive ROS