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doi: 10.1172/JCI65859

143 Noronha et al

Since it was discovered more than 40 years ago, much has been uncovered about this important chemical messenger

Key Functions of IGF-1 Stimulates protein synthesis in muscle tissue Promotes cell division (mitogenesis) Inhibits cell death (anti-apoptotic) Activates satellite cells - the stem cells of muscle Enhances nutrient uptake in muscle fibers Supports bone growth and density Promotes nerve tissue repair The Limitation of Native IGF-1 Despite its powerful effects, native IGF-1 has a significant limitation for research applications: extremely short half-life