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Description

10.1038/nrneurol.2017.185 Nat

Innovations in genomics and big data analytics for personalized medicine and health care: a review

In fact, aging as well as degenerative and neuropsychiatric diseases, such as Parkinsons disease, Alzheimers disease, autism and schizophrenia, are associated with increased ROS production, the disruption of cellular GSH pools, and downregulation of GSH-dependent enzymes ( Because GSH does not readily penetrate the blood-brain barrier (BBB) ( de novo synthesis by two enzymes: -glutamate-cysteine ligase (GCL) and glutathione synthetase (GS) (Valdovinos-Flores and Gonsebatt, 2012)