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[58] Brass EP, Koster D, Hiatt WR, Amato A.Vascular Medicine 2013

Ramskold, D

Recently, it was reported in an experimental colitis model that dextran sodium sulfate (DSS) treatment, a chemical agent known to induce colitis, elevated the c-Src-mediated tyrosine phosphorylation of occludin in a phospholipase D2 (PLD2)-mediated pathway in PLD2 knockout mice

The triple-agonist hypothesis predicts that GIP receptor activation, by enhancing insulin secretion and improving glycemic control, will offset the hyperglycemic effects of glucagon receptor activation while preserving its energy-expenditure benefits