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The AR +/hi BCL-2 + (LNCaP-AI) subtype of CRPC is similarly sensitive to BCL-2 inhibition Next, we examined the sensitivity of AR +/hi BCL-2 + subtype of CRPC to ABT-199 using the progressive LNCaP-AD 1 CRPC (AI) 2 CRPC (castration/Enza-resistant) models (Fig

The activation of TLR3 in these cells induces the stimulation of TRPML1, which, in turn, by inducing the release of lysosomal Ca 2+ into the extracellular environment, can promote the fusion of the plasma membrane with the lysosomal membrane and increase the release of ATP from the organelle (Beckel et al., 2018)

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Repeated injections in one spot cause scar tissue buildup and reduce absorption over time