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doi: 10.3389/fnins.2025.1515374 Received 22 October 2024 Accepted 03 February 2025 Published 20 February 2025 Volume 19 - 2025 Edited by Matilde Otero-Losada, National Scientific and Technical Research Council (CONICET), Argentina Reviewed by Michael Henderson, Van Andel Institute, United States Minyoung Oh, Asan Medical Center, Republic of Korea Lenora Higginbotham, Emory University, United States Updates Copyright 2025 Rosal, Martin and Strafella

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Although little is known about the pathophysiology of PTSD + AUD, PTSD and AUD have each been associated with marked dysfunction in brain glutamate (i.e., excitatory) and Gamma-Aminobutyric Acid (GABA) (i.e., inhibitory) systems, making these systems promising targets for pharmacological intervention