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Condensation of 6-formylpterin with the diester of p -aminobenzoyl-L-glutamic acid, followed by reduction of the Schiff base with sodium borohydride and hydrolysis, leads to folic acid 1,86,353,618

Current symptomatic treatments offer limited symptom improvement, highlighting the urgent need for new strategies, including lifestyle modifications

The prediction of colonic absorption in vitro can be challenging, and we have found that the judicious use of an animal model can help to tease out absorption-related issues, as is the case for most modified-release drug delivery development

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