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Studies on pyronaridine and other Mannich base antimalarials

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Studies have indicated that this inflammatory response involves both the innate and adaptive immune systems, characterized by an increase in the number of neutrophils in the airway lumen, along with heightened numbers of macrophages, T lymphocytes, and B lymphocytes in the lung tissue [135] (Figure 10)

ageing and oxidative stress 29,30 ], also allowing the discovery of new modes of action for compounds, as well as predicting off-target or side effects