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Symptoms of overmethylation can include: [23] Restless legs/pacing Hyperactivity High pain tolerance Histamine intolerance Sleep disorders Panic disorders Paranoia Insomnia Low libido ADHD Low motivation Depression Anxiety High levels of neurotransmitters (dopamine, norepinephrine, and serotonin) A high copper to zinc ratio Generally, undermethylation will result in symptoms more akin to depression and sluggishness, while overmethylation is usually linked to symptoms like hyperactivity and anxiety

515MO Phase Ib study of telisotuzumab vedotin (Teliso-V) and osimertinib in patients (Pts) with advanced EGFR-mutated (Mut), c-Met overexpressing (OE) non-small cell lung cancer (NSCLC): final efficacy and safety updates

Int J Environ Res Public Health 19:6370 Maia A, Oliveira J, Lajnef M et al (2019) Oxidative and nitrosative stress markers in obsessivecompulsive disorder: a systematic review and meta-analysis

Soil Sulfur Sources Differentially Enhance Cadmium Tolerance in Indian Mustard (Brassica junceaL.)