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3 Phosphatidylcholine metabolism as a central modulator of tumor-stroma dynamics 3.1 De novo synthesis (Kennedy pathway) The Kennedy pathway, which administers the de novo synthesis of PC, plays a central role not only in membrane biosynthesis but also in regulating tumor-stroma crosstalk within the TME

Methionine metabolism is dependent on adequate levels of B12, B6, magnesium, and folate