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In late-stage trials, people taking orforglipron lost an average of about 12% of their body weight over roughly 72 weeks , and head-to-head studies suggest it may outperform standard oral semaglutide tablets (Rybelsus) in both weight loss and blood sugar control

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How Cagrilintide Works: The Science Behind the Peptide Cagrilintide acts on amylin receptors in the brain, primarily targeting the area postrema and nucleus tractus solitarius, both of which influence hunger and satiety signals