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The instability of a mixed disulfide between roGFP2 and PfGrx was also supported by unsuccessful attempts to force and stabilize a Grx(SSR) species in titration experiments with roGFP2 C151 (SH) and up to 80 M PfGrx C88S (S 2 ) (Fig

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This approach provides a risk estimate derived from the aggregate effect of validated common risk alleles identified through GWAS, reflecting how multiple variants of modest effect jointly contribute to the polygenic nature of the disease