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Funding This article was supported by research grants from the National Natural Science Foundation of China (82271069, 82371040, 82122017, 81870642, 81970780, 81470613 and 81670835), Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission (23Y11909800), Outstanding Youth Medical Talents of Shanghai Rising Stars of Medical Talents Youth Development Program, Shanghai Municipal Health Commission Project (2024ZZ1025 and 20244Z0015)