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Description

A majority (75%) of Northern European patients have been found to have a mutation causing 57 kb deletion in the proximal region of CTNS , often extending to involve the upstream Sedoheptulose Kinase ( SHPK ) gene or into the adjacent Transient Receptor Potential Vanilloid-1 gene (TRPV1) [15,16]

This restriction is due to the rigid nature of the amide (peptide) bond

* Correspondence: Daniel H

Interestingly, we observed that glutamate accumulation led to CD36 up-regulation in T cells, which could be further elevated in the absence of cystine (Fig