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For example, glomerular endothelial cells, podocytes, or tubular epithelial cellsall involved in IgA nephropathy pathogenesismay also undergo ferroptosis or modulate mesangial cell ferroptosis via paracrine signaling, yet their roles in amplifying renal injury remain unaddressed

Traditionally, macrophages can be polarized into two distinct phenotypes, namely classically activated M1 macrophages and alternatively activated M2 macrophages (23)

Thus, the variant alleles are recessive, and homozygosity for the variant alleles confers a relative lack of response to anti-leukotriene therapy in approximately 5% to 6% of subjects with asthma

In contrast, the Clec4a4 + intestinal eosinophils reported by Wang et al (2022) were more prominent in our circulating eosinophil population, while the signature of Clec4a4 - eosinophils prevailed in the inflammatory eosinophils II