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J Medicinal Plants Res

Tofacitinib also significantly inhibits IL-22-induced CXCL1 and CXCL5 expression in human colonic tissues, suggesting that targeting the IL-22/CXC chemokine axis through JAK/STAT inhibition may be a viable therapeutic strategy

These limitations are amplified in metastatic disease, where substantial genetic divergence between primary tumors and individual metastatic lesions has been documented across lungs, breast, Squamous Cell Carcinoma (SCC), melanoma, and prostate cancers