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6.3 Targeting acid amino metabolism CB-839, also known as Telaglenastat, is a first-in-class, selective, reversible, and orally active glutaminase 1 inhibitor

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In addition to critically analysing the phytochemical responsible for modulating drug induced nephrotoxicity, this review paper thoroughly examines the phytochemicals such as flavonoids, tannins, triterpenes, phenolic compounds, alkaloids, phytosterol, saponins, and glycosides are key elements that modulate nephrotoxicity, as clearly illustrate in Fig

In a pentylenetetrazole-induced convulsion model in mice, topiramate pretreatment decreased GSH levels and increased MDA levels, suggesting that TPM negatively regulates oxidative stress (Agarwal et al., 2011)