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Despite RIC is classified as an autosomal recessive disorder, five of the seven Japanese patients with RIC in a retrospective study were compound heterozygous, and two were simple heterozygous with a single variant of the ATP8B1 or ABCB11 genes

Autopsies performed on individuals who died from causes other than thyroid cancer have revealed small PTCs in about 10% of cases, and this frequency has not changed since the 1970s

The PML/RAR oncoprotein is a direct molecular target of retinoic acid in acute promyelocytic leukemia cells

Apart from its role in the immune system, NADPH is required by the enzyme glutathione reductase to regenerate reduced glutathione, a key endogenous antioxidant that protects cells from oxidative stress [13]