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Circadian timekeeping in anticancer therapeutics: an emerging vista of chronopharmacology research

While the functions of the HEAT-repeats are relatively well-understood 21 , the roles of the IDR, due to its structural flexibility, which prevents its visualization in cryo-EM structures, remains largely unclear 20

First, LCS3 treatment induced GSH inhibition in VRK2-KO cells, reflected by decreased levels of GSH/GSSG, whereas no significant effect on TXNRD1 activity was verified by the same concentration of LCS3

e-mail: [email protected] This article was submitted to Frontiers in Experimental Pharmacology and Drug Discovery, a specialty of Frontiers in Pharmacology