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Early intervention for GI conditions not only supports B12 levels but also helps prevent a range of additional health problems

The growth culture media were supplemented with 4.5 mg/mL glucose, 50 g/mL uridine, and 100 g/mL pyruvate to compensate for respiratory metabolism defects

The results showed that CRC DTP cells exhibited reduced sensitivity to the modeling drugs, and were reversible, quiescent, and specifically sensitive to ferroptosis induced by GPX4 inhibitors due to the upregulated GPX4 and ferrous iron