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Dcouvert en 1973 par le biochimiste Loren Pickart dans le plasma sanguin humain, ce tripeptide-cuivre a fait l'objet de plus de cinq dcennies de recherches qui ont progressivement rvl l'ampleur de ses fonctions biologiques

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Their treatment plan may differ from the recommendations listed below due to factors like: underlying medical conditions age deficiency severity For example, the following are global recommendations for treating vitamin D deficiency rickets in infants and children ( Under 3 months old: 2,000 IU (50 mcg) oral supplements daily for 3 months Infants between 2 and 12 months old: 2,000 IU (50 mcg) oral supplements daily for 3 months or a single dose of 50,000 IU (1,250 mcg) Children 12 months to 12 years old: 3,0006,000 IU (75150 mcg) oral supplements daily for 3 months or a single dose of 150,000 IU (3,750 mcg) Children over 12 years old: 6,000 IU (150 mcg) oral supplements daily for 3 months or a single dose of 300,000 IU (7,500 mcg) After vitamin D levels have normalized, its recommended that babies under 12 months old receive a daily maintenance dose of 400 IU (10 mcg), while children 1 year or older receive a daily dose of 600 IU (15 mcg) ( Its also recommended that children and teens with vitamin D deficiency rickets maintain a daily calcium intake of at least 500 mg per day

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