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Science 292(5514):107110

Dysregulation in the glutamateglutamine cycle in the brain of animals exposed to strenuous exercise might contribute to the exercise-related central fatigue phenomenon [45]

During exercise, the muscle signals its energy requirements to the liver by changing the concentration of acylcarnitine in the blood, and the liver adjusts its metabolic activity to increase the synthesis and release of energy substances [223, 224], support muscle contraction and meet the energy demands of exercise [225, 226]

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