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Familial PD caused by a mutation in glucocerebrosidase ( GBA1 ) leads to the metabolic dysregulation of the important bioactive lipid ceramide and imbalance of its intermediate glucosylceramide (Plotegher et al., 2019)

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Hydration strategies: Aim for 6-8 glasses of fluid daily (about 1.5-2 litres), adjusting for activity level, climate and individual needs Sip fluids regularly throughout the day rather than consuming large volumes at once Monitor urine colour as a hydration indicatorpale straw colour suggests adequate hydration Consider oral rehydration solutions if experiencing diarrhoea or vomiting Moderate alcohol intake, which can worsen dehydration Note that caffeinated drinks count towards your fluid intake, though you may wish to moderate these if they worsen symptoms Note : If you have a condition requiring fluid restriction (such as heart failure or kidney disease), follow your healthcare provider's specific guidance on fluid intake