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Figure 6 5.2.1 Antioxidants Mitochondrial dysfunction is frequently associated with elevated oxidative stress levels, leading to cellular damage and exacerbating the inflammatory response (192)

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[DOI] [PubMed] [Google Scholar] 2.Wall BT, Stephens FB, Constantin-Teodosiu D, Marimuthu K, Macdonald IA, Greenhaff PL

To solve the paradox that pre-existing high concentrations of ROS in the TME can conversely inhibit immunity, the most advanced strategy is to develop multifunctional nanovaccines that first clear, then activate. Such vaccines can first use their material properties to scavenge the inhibitory ROS in the TME, creating a favorable environment for immune cells, and then strongly activate DCs by releasing immune agonists, ultimately triggering a systemic anti-tumor immunity [265]