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(Emoto et al., 2016) recently found a distinct change in microbial composition in individuals with coronary artery disease, with a large rise in Lactobacillales ( Firmicutes ) and a decrease in Bacteroidetes

It enables the intracellular degradation and recycling of damaged or redundant organelles and proteins, mainly through autophagosome formation and lysosomal degradation, serving dual roles in both physiological maintenance and pathological adaptation (Levine and Kroemer, 2019