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At first glance, this may seem an appropriate and straightforward way to quantify the treatment effect, but there are several reasons why the placebo-adjusted effect sizes of a drug in RCTs do not necessarily indicate the effect sizes that are achieved in real-life patient management

PMID: 18057338 View source Bowers CY, et al

Preparation and Administration: Where Most Protocols Fail AHK-Cu arrives as lyophilized powder requiring reconstitution with bacteriostatic water before injection