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Moreover, ferroptotic activation induces overexpression of matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS), which disrupts articular cartilage metabolic homeostasis and potentiates ECM degradation, thereby driving OA progression (Sheng et al., 2025)

The copper interaction anomalies in these proteins contribute to misfolding and aggregation that is linked to neurodegeneration

However, the fatty acid-derived peroxidation product which is sensed by OhrR in vivo remains to be identified

illuminate the critical role of acetate in enhancing T cell function within the TME, particularly in glucose-restricted conditions prevalent in cancer