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Rating: 4.6732000000000005 (12 reviews)

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Description

The SCFA-receptor interaction represents a direct molecular link in the gut-kidney axis, translating microbial metabolite production into renal protective signaling (Xiang et al., 2025)

The experimental work was mainly performed by MG

However, an overproduction of probiotic metabolites like peptidoglycan fragments or bacterial DNA can hyperactivate DCs via TLR2/9 or NOD2, boosting BAFF/APRIL production via NF-B/MAPK pathways, potentially triggering systemic autoreactive B cells and exacerbating SLE autoimmunity (139141)