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[82] also reported that the use of a dialysis membrane promotes uniform particle size distribution [82], which may otherwise vary due to batch-to-batch variation of precursors [79]

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Unfortunately, with the possible exception of LPS and I-FABP, validation of these assays against standard permeability measurements and proper clinical validation studies in large groups of patients are missing and can therefore not be recommended to replace the direct permeability tests described above

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