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10.1073/pnas.97.6.2940 83 KnstlerA.BacsR.GullnerG.HafezY

Most evidence comes from lab and animal studies, not controlled human trials

The drug-induced hypersensitization of the brain reward circuits is hypothesized to cause a pathological transition from drug liking to wanting that underlies compulsive substance use as previously demonstrated with chronic challenges of morphine, cocaine, ethanol, nicotine, and cannabinoids ( All mice were taken out from the IntelliCage once daily (in the morning) to receive their assigned 28-day drug sensitization regimen