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All properties of the formulations are mentioned in Supplementary Table S1 in the supplementary file after Dox loading

Compared with the CN group, the number of dark neurons in the Purkinje cell layer was notably reduced in the CP group (0.665 0.335/10 m 2 with P = 0.0117) and glycitin treatment groups [F (5, 30) = 14.16, P = 0.0029] at doses of 5, 10, and 20 mg/kg (0.495 0.165/10 m 2 with P = 0.0075, 0.18 0.18/10 m 2 with P = 0.0035, and 0.165 0.165/10 m 2 with P = 0.0033 respectively, Figures 4EI)

Calcium EDTA may support the mobilization and removal of heavy metals over a shorter treatment duration and is frequently incorporated into individualized detoxification plans based on laboratory findings and clinical assessment