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SARS-CoV-2 infection reprograms host folate and one-carbon metabolism at the PTM level to support de novo purine synthesis for replication of viral genome, through bypassing the viral shutoff of host translation 37

Whats more, its metabolite acetaldehyde may damage TJs of intestinal epithelial cells, destroy the intestinal barrier, cause pathological BT and intestinal leakage, and promote the progression of cirrhosis (Yan et al., 2023)