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Clinical studies of ASD and experiments on animal and cellular models of this disorder have revealed the biochemical endophenotype of insufficient mitochondrial energy production

In addition, heme derivatives released locally from damaged red blood cells within the abnormal neovasculature of cancers (Yin et al., 2015) and atheromas (Balla et al., 2007) seem much more likely to serve as the main sources of heme oxidant compounds in tissues throughout the body

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F., Ranieri, F., Toigo, G., Vasile, A., Ciman, M., Rizzoli, V., Moracchiello, M., and Campanacci, L