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The composition of the lung microbiome in lung cancer patients differs significantly from that in individuals without cancer, and this dysbiosis may indirectly affect neurological function via the release of proinflammatory cytokines and signaling molecules that promote tumor cell proliferation [136, 137]

doi: 10.3389/fimmu.2021.758281 65 VondraSHblerALLacknerAIRaffetsederJMihalicZNVogelAet al

PKC- inhibitor ruboxistaurin was shown to preserve tight junction integrity in clinical trials, and while it reduced vision loss, did not prevent DR progression (104)