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doi: 10.1016/j.chemosphere.2022.135196 81 NoulasC.TziouvalekasM.KaryotisT

Even if damage to the descending and ascending axons in white matter can not be prevented, interneurons present in gray matter may provide a means to rewire spinal cord circuits to restore some connectivity between the cortex and periphery (Courtine et al., 2008)

Decreased levels of hydroxyl radical (HO), peroxynitrite (ONOO - ), RO 2 , and singlet oxygen, and decreased expression of COX-2 and iNOS and NF-kB activation are all antioxidant effects of melatonin (318, 319), pointing to the possibility that melatonin is beneficial in UC by lowering inflammation and regulating OS

Our unpublished studies, as well as research results from other laboratories, indicate that minocycline, a tetracycline antibiotic, a microglia inhibitor and a MMP9 blocker, alleviates the development and symptoms of CIPN caused by oxaliplatin, cisplatin, paclitaxel and bortezomib [144,145,146,147,148]