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When the accumulation of lethal LPO exceeds the membrane's antioxidant defense and repair capabilities, related ion pumps or channels lose balance, disrupting ion homeostasis and ultimately leading to membrane rupture and ferroptosis (132,133)

Among the seven inhibitors used, only DFO and ferrostatin 1 were able to significantly prevent cell death, whereas CA074 only partially reduced cell death induced by TMZ, alone or in association with QN, in both cell lines (Fig