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In 1978, building on this discovery, Zamecnik and Stephenson 32 used specific oligodeoxynucleotide chains that target the 35S RNA of the Rous sarcoma virus to inhibit virus replication, marking a prototype for the application of antisense oligonucleotide (ASO) drugs in disease treatment

Histological findings further show thrombosis in terminal pulmonary arterioles and capillaries, as well as hyaline membranes lining the walls of alveoli, indicating high protein exudate from extensive capillary injury

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