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This imbalance can trigger the production of an array of ROS, such as NO, O 2 , H 2 O 2 , etc., which play important roles in the pathophysiological processes that drive gout inflammation [6]

Despite some cases of acute toxicities or symptomatic radionecrosis, combined HBOT with radiochemotherapy is noted to be safe and tolerable for patients (156, 163, 164)