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DISCUSSION The detrimental effects of kidney disease and nephrotoxicities include not only kidney failure but also impaired kidney structure and functionality as well as cardiovascular complications

Clinical studies have shown that it has several antiaging and cardio- and neuro-protective properties, and can also alleviate osteoarticular, urologic, and menopause-related discomfort.60 The extract has also been found to have a photoprotective, modulating effect on skin pigmentation.61 Several RCTs evaluating the use of French maritime pine bark extract have shown a significant reduction in signs of facial aging, such as wrinkles and solar lentigines,62,63 and increased levels of hyaluronan synthase and type I collagen.64 Another RCT (n=76) showed increased skin elasticity and hydration and decreased skin darkening in Asians working in highly polluted areas after treatment for 12 weeks.65 No relevant adverse effects were reported

In one study carried out on 2898 participants who lived in an area with factory-released dioxin, 425 diabetes (14.7%) subjects were identified, and a higher serum dioxin level is a risk factor for developing diabetes mellitus (Huang et al