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Vitamin B12 deficiency is also now considered to be a common side effect in patients receiving metformin treatment (0ften used to treat diabetes), particularly if patients are receiving a higher dose, longer treatment duration or have existing risk factors

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Genetic variations that make the recycling of glutathione less efficient

Several in vitro and in vivo therapeutic studies have shown that SOD2 lipophilic mimic, Mn (III) meso-tetrakis (N-n-hexylpyridinium-2-yl) porphyrin, (H2O) MnTnHex-2-PyP5 + (MnHex) can cross the BBB and accumulate in mitochondria than cytosol (Leu D et al., 2017