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In atherogenesis, enhanced glycolysis further increases lactate production and release [46], which leads to extracellular acidification, increases EC permeability, and accelerates atherosclerosis progression [47]

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It catalyzes the reduction of hydrogen peroxide (H2O2) and a variety of organic hydroperoxides (R-O-O-H) to water and the corresponding stable alcohols (R-OH) using glutathione as the reducing reagent, thus inhibiting the formation of free radicals and protecting the cells from oxidative damage

Effect of miR-155 knockdown on the reversal of doxorubicin resistance in human lung cancer A549/dox cells