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FIGURE 1 2.2.1 Physiologically based pharmacokinetic (PBPK) model To define the proper liver drug input, a representative overdose patient-specific physiologically based pharmacokinetic (PBPK) model adapted from Equation 1): where is the arterial concentration of APAP, is the portal venous concentration of APAP following gut absorption, and are the respective blood flow rates, and is the liver volume

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However, some serious idiosyncratic adverse reactions associated with targeted covalent inhibitors are immune-mediated reactions that can lead to significant mortalities