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As various factors such as genetic inheritance, environmental toxins, oxidative stress, and mitochondrial dysfunction are probably involved in the pathogenesis of the disease, it is very challenging to understand the pathogenesis of Parkinson's disease

There are also no validated dosing guidelines for DSIP, which compounds the risk: an unvalidated dose paired with a product of unverified identity is a poor foundation for any clinical decision

Complementing this, the use of a subunit boost vaccine formulated with an adjuvant directs the immune response toward the expansion of Th1 responses 32 , while using a distinct pathway of antigen delivery, processing and presentation